Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma
نویسندگان
چکیده
منابع مشابه
Metabolite profiling identifies pathways associated with metabolic risk in humans.
BACKGROUND Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. METHODS AND RESULTS To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinc...
متن کاملMetabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.
The discovery of metabolite-phenotype associations may highlight candidate biomarkers and metabolic pathways altered in disease states. We sought to identify novel metabolites associated with obesity and one of its major complications, nonalcoholic fatty liver disease (NAFLD), using a liquid chromatography-tandem mass spectrometry method. In 997 individuals in Framingham Heart Study Generation ...
متن کاملMetabolite profiling in Arabidopsis.
Metabolite profiling is the multiparallel relative quantification of a mixture of compounds or compound classes using chromatography and universal detection technologies (GC-MS, LC-MS). In this respect it is an extension of classical single-target methods from which it can be distinguished by its broader view on profiling major biochemical events. This broader scope of analysis outweighs the di...
متن کاملMetabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke.
BACKGROUND AND PURPOSE There is limited information about changes in metabolism during acute ischemic stroke. The identification of changes in circulating plasma metabolites during cerebral infarction may provide insight into disease pathogenesis and identify novel biomarkers. METHODS We performed filament occlusion of the middle cerebral artery of Wistar rats and collected plasma and cerebro...
متن کاملMetabolite profiling in blood plasma.
Metabolite profiling has been established as a multiparallel strategy for relative quantification of a mixture of compounds or compound classes using chromatography and universal detection technologies (gas chromatography-mass spectrometry [GC-MS], liquid chromatography-MS). Despite its origins dating back to the late 1960s, it was only in the 1980s that its use was acknowledged to diagnose met...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2018
ISSN: 0014-5793,1873-3468
DOI: 10.1002/1873-3468.13294